This second year of the Women's March also comes in the middle of the #MeToo movement, which has shed light on sexual misconduct and ushered in social change in a bevy of industries. It also comes months ahead of the midterm elections in the United States, in which progressive women hope to turn their activism into victories at the ballot box.
In Washington, where one year ago hundreds of thousands of women clad in pink hats took to the streets and vowed to resist Trump's presidency, Heather Tucci said she didn't want to stay on the sidelines.
"Before Trump, I was content to sit back and watch the government just go by me. Now I'm not," Tucci, from Harford County, Maryland, told CNN. "It is dire that we do something because it is just ridiculous what is happening to this country, what people think about us around the world and just undermining the basic fundamentals of humanity and the constitution and what democracy should stand for."
Kelley Robinson, Planned Parenthood's national organizing director, told CNN that it's "nothing new for women to be involved in elections," but said that many women who marched last year had been
spurred to run for office themselves.
"It's a time where we're not just showing up -- folks are saying that, 'Hey, we actually need to be sitting in those chairs,'" Robinson said. "You know, so everyone who was out in the airports rallying last year and marching in the streets, many of them are now sitting in state legislatures across the country. It's a powerful moment that we're in."
That movement, Robinson added, "is evolving into something more powerful every single day."
The protests did not go unnoticed by the White House. On Saturday, Trump tweeted that it's "a perfect day for all Women to March."
"Beautiful weather all over our great country, a perfect day for all Women to March," Trump wrote. "Get out there now to celebrate the historic milestones and unprecedented economic success and wealth creation that has taken place over the last 12 months. Lowest female unemployment in 18 years!"
Marchers gathered across the country and around the world hours after much of the United States federal government shut down after members of Congress failed to reach an agreement on a spending measure, casting uncertainty over much of the nation. Marchers, however, stayed the course.
One of the largest demonstrations unfolded Saturday in Los Angeles.
Kathleen Whitehead and her 13-year-old daughter, Casey Feldman, arrived early to that march. Feldman carried a green sign that said, "Respect Existence or Expect Resistance."
"The battle against women and health care is killing us," Whitehead told CNN. "It is 2018. I am 46 years old. My mother had to do this battle. Why do I, why? We have gone the wrong way."
Gioconda Aviles came to the Los Angeles march with her 9-year-old twin daughters.
"I think women are more empowered this year," Aviles, who attended the march last year as well, told CNN. "I can't believe we have the president we have. I'm Latina, pushed to get Latinos to vote. Clearly we didn't do a good job. I think we need to make the difference in 2018."
June Williams and her hausband, Carlos, said their motivations for marching have shifted since the inaugural Women's March.
"Last year was, we were angry that a person can get into office with his record and past," Williams said of Trump. "Hey, there's a lot of us who don't agree. He's not our president. This year for me, it's about equal status for women. Without people getting out and voting, look what happens."
In Denver, Stephanie Rundick wore a bright pink tutu and carried a sign that read, "Hands off my TuTu."
"There is not a more important time in history than now for the future for both women and men in making a statement that these are not the principals our country was founded on," she told CNN.
Leslie Prassas, 61, came to the Denver march from Fort Collins, Colorado. She missed the first Women's March, and said she wanted to stand shoulder to shoulder with like minded people who oppose Trump.
"It's just unbelievable how it ever came to this. It's sad and it's scary"
In New York, march participants raised their middle fingers as they went past the Trump International Hotel.
Maura O'Meara, 47, of New Paltz, organized a group of women from the Hudson Valley area to travel to New York City together to participate in the March. She said her motivations for marching are largely the same as last year, when she traveled to DC, but have gained new urgency.
"We haven't been quiet since last year. We've been up and out trying to fight for the rights of women and the vulnerable," she said. "I actually have more hope now."
CNN's Sophie Tatum, Miguel Marquez, Kyung Lah, Alexander Marquardt, Sara Weisfeldt and Emanuella Grinberg contributed to this report.