piątek, 13 grudnia 2013

Fwd: Phys.org Newsletter Tuesday, Dec 10



---------- Forwarded message ----------
From: Newsletter Phys.org <not-for-reply@physorg.com>
Date: Wed, Dec 11, 2013 at 2:00 AM
Subject: Phys.org Newsletter Tuesday, Dec 10
To: Pascal Alter <pascal.alter@gmail.com>


Dear Pascal Alter,

Here is your customized Phys.org Newsletter for December 10, 2013:

Spotlight Stories Headlines

- When liquids behave like solids
- NASA Mars spacecraft reveals a more dynamic red planet
- The dynamic cytoskeleton in bacterial cell division
- Father's diet before conception plays crucial role in health of his offspring, study suggests
- Study unlocks secret of how fruit flies choose fruit with just the right amount of ethanol
- Resistant flu virus keeps contagiousness
- Students' robotic arm can make you stronger
- Bid to colonize Mars wins high-profile backing
- Nobel winning scientist to boycott top science journals
- Juno spacecraft hears amateur radio operators say 'Hi'
- Titanium powder used to 3D print automotive parts
- New findings reveal protein structure in rubella virus
- Don't worry about getting fried by gamma ray burst, researchers say
- Juno gives starship-like view of earth flyby
- An isotopic analysis of two mass extinction events

Astronomy & Space news

New views of Mars from sediment mineralogy
The first detailed examination of clay mineralogy in its original setting on Mars is offering new insights on the planet's past habitability, research led by Planetary Science Institute Senior Scientist David T. Vaniman has found.

Image: Siding Spring Observatory reveals stellar nursery
Illuminated by the light of nearby stars, the nebula M-78 exhibits a ghostly appearance in this 10-minute exposure taken with a 6" refractor at the Siding Spring Observatory in Australia.

Video: Mars 360: The North Pole
Enjoy views of the martian north pole from all angles in this new animation from ESA's Mars Express.

Kennedy Space Center receives NASA's Tracking and Data Relay Satellite
(Phys.org) —NASA's newest Tracking and Data Relay Satellite (TDRS) is in a temporary home at the agency's Kennedy Space Center in Florida waiting to be attached to a United Launch Alliance Atlas V rocket that will take it into Earth orbit Thursday, Jan. 23.

Q&A: Curiosity's spectacular Yellowknife Bay side-trip
When the Curiosity rover landed in Gale Crater on Mars in August 2012, its primary destination was Mount Sharp, a three-mile-high mound a few miles south of the rover's landing site. But before making for the mountain, mission planners and scientists decided to take a slight detour to the North. Orbital instruments had spied an interesting-looking region of rock outcrop between the mountain and the crater rim. Because the rover had landed about a quarter-mile from this spot, it seemed worth popping up to take a look before proceeding to Mount Sharp, where the Curiosity is headed now.

Johns Hopkins APL will launch RAVAN to help solve an earth science mystery
(Phys.org) —A new, low-cost cubesat mission led by the Johns Hopkins Applied Physics Laboratory in Laurel, Md., will demonstrate technology needed to measure the absolute imbalance in the Earth's radiation budget for the first time, giving scientists valuable information to study our climate.

Comet ISON pronounced dead; Sun is chief suspect
Comet ISON, once optimistically called the comet of the century, is dead, the victim of a way-too-close brush with the sun. It was barely a year old.

Astrophysicists launch ambitious assessment of galaxy formation simulations
(Phys.org) —One of the most powerful tools for understanding the formation and evolution of galaxies has been the use of computer simulations—numerical models of astrophysical processes run on supercomputers and compared with astronomical observations. Getting computer simulations to produce realistic-looking galaxies has been a challenge, however, and different codes (simulation programs) produce inconsistent results.

Drawing the line between stars and brown dwarfs
(Phys.org) —Stars come in a tremendous size range, from many tens of times bigger than the Sun to a tiny fraction of its size. But the answer to just how small an astronomical body can be, and still be a star, has never been known. What is known is that objects below this limit are unable to ignite and sustain hydrogen fusion in their cores: these objects are referred to as brown dwarfs.

Bid to colonize Mars wins high-profile backing
A Dutch entrepreneur's bold quest to colonize Mars won high-profile support Tuesday from a US aerospace giant, although the timetable for putting humans on the red planet has been pushed back two years.

Moons of Jupiter and Saturn could have been seeded with life
Life on Earth or Mars could have been brought to the moons of Jupiter or Saturn on rocks blasted off those planets, researchers say.

Europe aims for first comet landing Nov. 11 (Update 2)
It's been likened to a parachutist trying to land on a mountaintop. Or a person attempting to leap from one speeding car to another.

Juno spacecraft hears amateur radio operators say 'Hi'
(Phys.org) —Thousands of amateur (ham) radio operators around the world were able to say "Hi" to NASA's Juno spacecraft Oct. 9 as it swung past Earth on its way to Jupiter.

Don't worry about getting fried by gamma ray burst, researchers say
(Phys.org) —If recent news that University of Alabama in Huntsville (UAH) researchers observed the largest gamma ray burst ever has you nervous about getting blasted into extinction by a massive burst from space, the UAH researchers have good news.

Juno gives starship-like view of earth flyby
(Phys.org) —When NASA's Juno spacecraft flew past Earth on Oct. 9, 2013, it received a boost in speed of more than 8,800 mph (about 7.3 kilometer per second), which set it on course for a July 4, 2016, rendezvous with Jupiter, the largest planet in our solar system. One of Juno's sensors, a special kind of camera optimized to track faint stars, also had a unique view of the Earth-moon system. The result was an intriguing, low-resolution glimpse of what our world would look like to a visitor from afar.

NASA Mars spacecraft reveals a more dynamic red planet
(Phys.org) —NASA's Mars Reconnaissance Orbiter has revealed to scientists slender dark markings—possibly due to salty water - that advance seasonally down slopes surprisingly close to the Martian equator.

Medicine & Health news

Majority of Americans avoid addressing end-of-life issues, new study finds
During the past two decades, high-profile legal cases surrounding end-of-life decisions have received widespread attention in the United States, prompting increased media focus and numerous debates on the subject.

Contractors who worked in conflict zones suffer high rates of PTSD, depression
Private contractors who worked in Iraq, Afghanistan or other conflict environments over the past two years report suffering from post-traumatic stress disorder and depression more often than military personnel who served in recent conflicts, according to a new RAND Corporation study.

Founder of French breast implant scandal firm jailed (Update 2)
The founder of a French firm whose faulty breast implants sparked a global health scare was sentenced to four years in jail Tuesday after being convicted of fraud.

CMS finalizes 2014 physician payment rates, policies
(HealthDay)—The final payment rules for 2014 include a proposal to support care management outside the routine office interaction and policies to promote high quality care and efficiency, according to a report from the Centers for Medicare & Medicaid Services (CMS).

Gastroenterology research uncovers new route for the development of anti-diarrhoeal drugs
New gastroenterology research carried out by the RCSI (Royal College of Surgeons in Ireland) in conjunction with Trinity College Dublin and Johns Hopkins University in Baltimore, Maryland has uncovered a new route for the development of anti-diarrhoeal drugs. The new route directly targets cells and molecular processes that control water movement into the intestine and may help with the development of a new class of anti-diarrhoeal medication.

Research teams unite for research on Lou Gehrig's Disease
Lisa Miller and Paul Gelfand, biophysical chemists at the U.S. Department of Energy's Brookhaven National Laboratory, recently visited the Advanced Photon Source at Argonne National Laboratory to supplement their research into the cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Professor offers suggestions for coping with grief during holidays
The holiday season can be a difficult time for someone who has experienced the death of a loved one. The emphasis on family togetherness and traditions can bring feelings of sadness, loss and emptiness, and the sights and sounds can trigger memories of the one who has gone.

Understanding impulsive behaviour
Helping offenders to control their impulses can reduce the risk of re-offending and help with anger control, according to research from Victoria University of Wellington.

Study calls for better support for fathers of children with cleft lip or palate
Research psychologist Nicola Stock says fathers need better support to enable them to deal with the challenges of having a child born with a cleft lip or palate. Her research shows that appropriate support is not yet available to fathers even though they play a key role in their child's development and family well-being.

Largest clinical trial for potential new psoriasis treatment
Novartis Pharmaceuticals UK has announced the launch of the UK's largest clinical trial to investigate a potential new biologic treatment for adults with moderate-severe psoriasis.

Confronting secondary injuries from brain trauma
Every day, thousands of people nationwide are hospitalized or treated in emergency rooms as a result of traumatic brain injuries, from mild concussions to the most severe cases. Yet the initial incident may not be the sole determining factor in a patient's outcome. Instead, it's what comes in the days after that injury that could have the most impact.

Sensory technology provides daily dietary guidance
An innovative new way of providing personal behavioural guidance to children and young adults could play a crucial role in tackling the ongoing obesity epidemic. The EU SPLENDID project, which is being coordinated by the Aristotle University of Thessaloniki in Greece, will use high-tech sensors to record eating habits and physical activity across the course of a day, and provide valuable - and accurate - information to users and health-professionals.

Developing affordable hearing aids for third-world children
Norwegian researchers are developing a simple and cheap hearing aid that can be adapted to compensate for a child's hearing loss without the need for specialists. The aim is to help more people in the third world.

Nursing methods seek rural health care improvements
It's not a matter of numbers but location.

Avoid holiday decorating hazards
Holiday decorating is supposed to be a joyous time. But without the proper precautions, it can be dangerous—even deadly. So before you pull those light strings out of the basement and set your ladder up against the side of the house, consider the following: according to the Centers for Disease Control, almost 18,000 people have been treated in Emergency Rooms during the holidays for fall-related injuries during the past four years.

Young offenders exhibit disastrous health profiles
Young people serving time in youth detention or serving community-based orders have extremely high rates of substance dependence, poor mental health and engage in risky sexual behaviour, a new study has found.

Qatar launches gene mapping to combat diseases
The Gulf state of Qatar on Tuesday launched a genetic code mapping project for its small population to help in treating diseases.

US boosts mental health funding, year after Newtown (Update)
US Vice President Joe Biden announced a $100 million boost in funding for mental health services on Tuesday as he met families of children killed in the Newtown school shooting, the White House said.

Algorithms resolve kidney crossmatch allocation
Diseased kidneys can be replaced by a living donation from a healthy person. Often family members or friends volunteer their kidney for transplanting. A prerequisite is that the tissue of the donor and the recipient is immunologically compatible. In approximately one fifth of cases this is not the case. For this reason, highly sensitised people, who have already undergone transplantation, were pregnant or who have received blood, often more than others have to wait many years for a new kidney. Now at the MedUni Vienna a so-called "crossover transplantation" has been successfully carried out at the Vienna General Hospital with the use of innovative computing algorithms. With the setting up of a systematic crossover programme the waiting time can be significantly reduced.

Embolic material at site of fatal hemorrhage occurring days after flow-diversion aneurysm treatment
It started as a medical mystery and became a cautionary tale. Fatal hemorrhages occurred in the brains of two patients several days after successful cerebral aneurysm treatment with the Pipeline Embolization Device (PED). These hemorrhages were located in the same vascular territory as the treated aneurysms but were not close enough to the lesions to be directly linked to the aneurysms or their treatment. Over time, physicians began to suspect that these were not isolated hemorrhages, but in fact, were occurring in approximately 4% of patients treated in this manner. In the second patient (Case 1 in this paper), embolic non-biological material had been found close to the site of hemorrhage, but the nature of the material and its relationship to the hemorrhage was unclear. When a third patient at a distant institution (Case 2) developed a similar delayed hemorrhage, the treating physicians were advised to check carefully for the presence of embolic foreign material. When the material was confirmed to be present in the third patient (Case 2), preserved tissue from the first patient (Case 3) was re-examined and the embolic material, albeit in lesser amounts, was identified adjacent to the hemorrhagic area. The source of this material became the next question to answer.

Home testing devices could monitor epilepsy drug levels, reduce clinical visits
Medications remain the mainstay of epilepsy treatment, and to date there are no FDA-approved devices that provide an accurate means of detection for generalized tonic-clonic seizures (GTCS), or convulsions, during activities of daily living. Two new studies presented at the American Epilepsy Society's 67th Annual Meeting in Washington D.C. provide data that warrants the development of non-invasive devices with the capability to signal the onset of an epileptic seizure and could be crucial to optimal patient dosing.

Strong state alcohol policies protective against binge drinking
According to a new study, a novel composite measure consisting of 29 alcohol policies demonstrates that a strong alcohol policy environment is a protective factor against binge drinking in the U.S. The study was led by researchers at the Boston University Schools of Medicine (BUSM) and Public Health and Boston Medical Center (BMC), and is published in the current issue of the American Journal of Preventive Medicine.

First the hype, now the science: Evidence-based recommendations for PRP
Platelet-rich plasma (PRP) has grabbed headlines in recent years for its role in helping some of sports' biggest stars return to play following injury –including golfer Tiger Woods, Super Bowl winner Hines Ward and NBA legend Kobe Bryant.

Money may corrupt, but thinking about time can strengthen morality
Priming people to think about money makes them more likely to cheat, but priming them to think about time seems to strengthen their moral compass, according to new research published in Psychological Science, a journal of the Association for Psychological Science.

Gut microbes affect MicroRNA response to bacterial infection
When it comes to fighting off pathogens like Listeria, your best allies may be the billions of microorganisms that line your gut, according to new research published in mBio, the online open-access journal of the American Society for Microbiology. The study reveals that germ-free mice are more susceptible to infection with the foodborne pathogen Listeria monocytogenes than mice with conventional intestinal microbiota.

Antibiotic-resistant typhoid likely to spread despite drug control program
Restricting the use of antibiotics is unlikely to stop the spread of drug resistance in typhoid fever, according to a study funded by the Wellcome Trust and published in the journal eLife.

Early puberty in girls might be linked to bad behavior
(HealthDay)—Girls who hit puberty early might be more likely than their peers to get into fights or skip school, a new study suggests.

Arthrodesis ups complications, costs for spondylolisthesis
(HealthDay)—For patients with lumbar spondylolisthesis, decompressive laminectomy and spinal arthrodesis is associated with lower reoperation rates, but with higher complication rates and higher overall costs than laminectomy alone, according to a study published in the Nov. 6 issue of The Journal of Bone & Joint Surgery.

With looming ACA uncertainty, budget exercise necessary
(HealthDay)—Constructing a budget for 2014 is critical for physicians even with the uncertainties surrounding the Affordable Care Act, according to an article published Nov. 10 in Medical Economics.

Pot smoking in pregnancy tied to stillbirth risk
(HealthDay)—Expectant mothers who smoke marijuana may triple their risk for a stillbirth, a new study suggests.

Doctors' group urges tighter controls on prescription painkillers
(HealthDay)—Abuse of narcotic painkillers and other prescription drugs is a growing problem in the United States, and a leading doctors' group is urging members to exercise tighter control on the medications.

Stage III/IV melanoma patients at risk for new primaries
(HealthDay)—Patients with stage III or IV melanoma who have not received treatment with BRAF inhibitors remain at risk for developing new primary melanomas (NPMs), although the incidence rates are lower than those observed in studies of dabrafenib and vemurafenib, according to research published online Dec. 2 in the Journal of Clinical Oncology.

Does 24/7 intensivist coverage impact housestaff skills?
(HealthDay)—Pediatric intensivists and housestaff have concerns regarding the preparation of housestaff after being trained in a 24/7 in-house (or in-hospital [IH]) attending model, according to a study published online Dec. 9 in Pediatrics.

Health information technology may cut demand for physicians
(HealthDay)—Health information technology (IT) may cut demand for physicians in the future, according to a review published in the November issue of Health Affairs.

Improved screening must balance potential benefits with patient harms
Screening to detect medical conditions has become standard practice for many diseases, but insufficient attention has been paid to the potential for harm, according to research conducted at the University of North Carolina.

'Hung-over driving' as dangerous as drunk driving
A hangover following a night of heavy drinking can impair driving performance as much as driving under the influence of alcohol, according to new research by Associate Professor Chris Alford of the University of the West of England and Assistant Professor Joris Verster of Utrecht University.

Anti-tumor activity of immune cells can be restored
The Leuven-based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth. They have also demonstrated that blocking the protein Nrp1 can restore this anti-tumor immune response. This is a first. Nrp1 may provide an important hub for the development of new therapies against cancer.

Music brings memories back to the brain injured
In the first study of its kind, two researchers have used popular music to help severely brain-injured patients recall personal memories. Amee Baird and Séverine Samson outline the results and conclusions of their pioneering research in the recent issue of the journal Neuropsychological Rehabilitation.

32 percent decline in New Jersey rate of infant-parent bed sharing
While a large national study in the Journal of the American Medical Association (JAMA) has shown that bed-sharing with a parent is increasing for African-American infants, putting them at higher risk for Sudden Infant Death Syndrome (SIDS), New Jersey's black residents appear to be bucking the trend.

Consumers find HealthCare.gov more user-friendly
(HealthDay)—Americans trying to buy health insurance through the federal government's online health care exchange are having an easier time navigating the initially dysfunctional system, consumers and specialists say.

Novel cancer cell DNA damage repair mechanism unveils
Research with a Finnish background facilitates the development of more effective cancer medication

A step closer to muscle regeneration
(Medical Xpress)—Muscle cell therapy to treat some degenerative diseases, including Muscular Dystrophy, could be a more realistic clinical possibility, now that scientists have found a way to isolate muscle cells from embryonic tissue.

Limits of memory retrieval allow us to live in the present
Renowned violinist Louise Owen is sitting across from CBS News correspondent Lesley Stahl when Stahl asks Owen to recall what she did two decades ago, on April 21, 1991.

Five-minute intervention can help patients with substance and behavioral problems
A brief 5 to 10 minute intervention in an emergency department can provide effective help to patients with substance and behavioral problems, and should be broadly implemented, say the authors of a new Yale study. Their recommendations appear in the December issue of Health Affairs.

Parents support anti-bullying policies that protect overweight students
Parents, both with and without overweight children, are concerned about weight-based bullying and are in favor of a range of policy initiatives to address the issue, according to two new studies published this month by researchers at the Yale Rudd Center.

One-in-three older diabetic adults have impaired thinking
Type 2 diabetes can dramatically affect the everyday thinking skills of up to one-in-three adults aged more than 60, a new study has found.

Use of spanking exacerbates aggressive child behavior
A mother's affection after she spanks her child does little to diminish the negative impact of the act, a new University of Michigan study finds.

Ultrasound microscopy: An aid for surgeons to make the invisible, visible
Professor Naohiro Hozumi of Toyohashi Tech is developing the technology to monitor living tissue and cell specimens for medical purposes.

Less painful drug delivery for pediatric leukemia patients is safe, effective
Children with acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful intramuscular injection for more than 40 years, research suggests.

A rising tide lifts all boats: Study links broader health insurance in Massachusetts with better health and care
In 2006, Massachusetts was on the same brink that the entire nation is on today: the brink of expanding health insurance to cover far more people than before, through government-driven, market-based reform.

Drug-antibody pair has promising activity in non-Hodgkin lymphoma
A toxin linked to a targeted monoclonal antibody has shown "compelling" antitumor activity in patients with non-Hodgkin lymphomas who were no longer responding to treatment, according to a report from Dana-Farber Cancer Institute.

Engineering prosthetic voices
"Never heard me before." That's what William, a 9-year-old boy with a speech-language disorder, said the first time he used the prosthetic voice that Northeastern associate professor Rupal Patel made just for him.

Metastudy on correlations of sports participation and substance abuse
Following a review of published studies, McMaster researchers have found that participation in sport raises the chance of adolescents and young adults abusing alcohol.

How does H. influenzae thrive in COPD patients?
It can be almost painful to watch individuals with chronic obstructive pulmonary disease (COPD) breathe. When they're not coughing, they're fighting for every breath. Approximately 24 million Americans struggle with COPD—which typically worsens over time and is the third most common cause of death.

Risky pregnancy for first-time mothers age 30-34
New research from Karolinska Institutet shows that the risk of giving birth to your first child in advanced years increase as early as in the 30-34 age group. Previously, first-time mothers were categorised as being in advanced years from the age 35. The results, which are based on the Swedish and Norwegian medical birth registers, have been presented in the scientific journal Obstetrics and Gynecology.

Review calls for increased attention to cancer risk from silica
A new review highlights new developments in understanding the health effects of silica, and calls for action to reduce illness and death from silica exposure at work, including stronger regulations, heightened awareness and prevention, and increased attention to early detection of silicosis and lung cancer using low dose CT scanning.

Multimaterial 3D printers create realistic hands-on models for neurosurgical training
Researchers from the University of Malaya in Malaysia, with collaboration from researchers from the University of Portsmouth and the University of Oxford in the United Kingdom, announce the creation of a cost-effective two-part model of the skull for use in practicing neurosurgical techniques. The model, produced using the latest generation of multimaterial 3D printers, is composed of a variety of materials that simulate the various consistencies and densities of human tissues encountered during neurosurgery. Details on the model are provided in "Utility of multimaterial 3D printers in creating models with pathological entities to enhance the training experience of neurosurgeons. Technical note." By Vicknes Waran, F.R.C.S.(Neurosurgery), Vairavan Narayanan, F.R.C.S.(Neurosurgery), M.Surg., Ravindran Karuppiah, M.Surg., Sarah L. F. Owen, D.Phil., and Tipu Aziz, F.Med.Sci., published today online, ahead of print, in the Journal of Neurosurgery.

New method to study secondary breast cancer metastasis
Research led by scientists at King's College London has discovered a new way to study the mechanisms that cause breast cancer cells to spread to the bone.

Coping with stress management during final exams
If it were as easy as the movies depict, studying for final exams would be a three-minute montage of library visits and late-night study sessions set to pop music, but in the real world students often find themselves surrounded by textbooks, outlines and deadlines as they engage in a 'round-the-clock study schedule during the end of the semester.

Similar reward effect of sugar-free and 'normal' breakfast drinks
Do light products taste worse after repeated exposure? Or does the body gradually learn that they contain fewer calories and that is why we grow to like them less? In collaboration with dairy cooperative FrieslandCampina, a research team from Wageningen University studied the reward effect of sugar-free and 'normal' breakfast drinks. They concluded that light products taste equally good after repeated exposure, as reported in the on-line scientific journal Plos One on 4 December.

Barriers and molecular trains trap Joubert syndrome protein in cilia
(Medical Xpress)—A cilia disease protein causing Joubert Syndrome, ARL-13, is actively trafficked across the base of cilia and molecular diffusion barriers prevent its exit, according to new research from the UCD Conway Institute published in PLoS Genetics.

WHO sees first chikungunya cases in western hemisphere
Cases of chikungunya have occurred on the Caribbean island of Saint Martin, marking the first time the mosquito-borne disease has spread in the western hemisphere, the World Health Organisation (WHO) said on Tuesday.

Could poor dental health signal a faltering mind?
(HealthDay)—Tooth loss and bleeding gums might be a sign of declining thinking skills among the middle-aged, a new study contends.

Vancomycin powder doesn't cut infection post-spine surgery
(HealthDay)—For patients undergoing spinal procedures, the local application of vancomycin powder in surgical wounds does not significantly reduce the incidence of infection, according to a study published in the Dec. 1 issue of Spine.

ASH: Mutation in GFI1B causes gray platelet syndrome
(HealthDay)—A mutation has been identified in the gene encoding the transcription factor growth factor independent 1B (GFI1B), which causes gray platelet syndrome, according to a study published online Dec. 10 in the New England Journal of Medicine. The research was published to coincide with presentation at the annual meeting of the American Society of Hematology, held from Dec. 7 to 10 in New Orleans.

Wider statin use recommended for chronic kidney disease
(HealthDay)—New guidelines for lipid management in chronic kidney disease (CKD) recommend wider statin use, according to a clinical practice guideline published online Dec. 10 in the Annals of Internal Medicine.

ASH: CALR mutations ID'd in myeloproliferative neoplasms
(HealthDay)—Many patients with myeloproliferative neoplasms without mutations in the Janus kinase 2 gene (JAK2) or in the thrombopoietin receptor gene (MPL) have mutations in the CALR gene encoding calreticulin, according to two studies published online Dec. 10 in the New England Journal of Medicine. The research was published to coincide with presentation at the annual meeting of the American Society of Hematology, held from Dec. 7 to 10 in New Orleans.

Europe: Diet sweetener aspartame is safe in cola
The European Food Safety Authority has found that the artificial sweetener aspartame is safe for people to consume at the levels currently used in diet soft drinks.

Acid-suppressing medications associated with vitamin B12 deficiency
Use for 2 or more years of proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) was associated with a subsequent new diagnosis of vitamin B12 deficiency, according to a study appearing in the December 11 issue of JAMA.

Use of CPAP for sleep apnea reduces blood pressure for patients with difficult to treat hypertension
Among patients with obstructive sleep apnea and hypertension that requires 3 or more medications to control, continuous positive airway pressure (CPAP) treatment for 12 weeks resulted in a decrease in 24-hour average and diastolic blood pressure and an improvement in the nocturnal blood pressure pattern, compared to patients who did not receive CPAP, according to a study appearing in the December 11issue of JAMA.

Police activities in Thailand may lead to riskier behaviors in people who inject drugs
Recent increasing police activities focused on people who inject drugs in Thailand have involved reported injustices that may lead to riskier behaviors in people who inject drugs (PWID), according to a study published this week in PLOS Medicine. The results of the study, by Thomas Kerr and colleagues, from the University of British Columbia, Canada, found that urine drug testing, which has become widely available since around 2000, was identified as a key tool used by the police, with some police requesting PWID to provide urine samples in public places.

Experimental compound dramatically reduces joint inflammation
An experimental compound synthesized and developed by scientists from the Florida campus of The Scripps Research Institute (TSRI) has the capacity to significantly reduce joint inflammation in animal models of rheumatoid arthritis, an autoimmune disease that affects more than two million Americans.

Caution to pregnant women on red meat diabetes link
(Medical Xpress)—Pregnant women and women planning to become pregnant can make use of the summer holiday season to adjust their diets and reduce the risk of gestational diabetes, according to researchers at the University of Adelaide's Robinson Institute.

SIRT5 regulation of proteins involved in metabolism
The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation. In a new study published in the Dec. 3rd 2013 issue of Cell Metabolism, Buck Institute researchers have now identified widespread regulation of proteins involved in metabolism by the mitochondrial sirtuin, SIRT5. Using a novel quantitative proteomic method developed at the Buck Institute, the Gibson lab in collaboration with Eric Verdin's group at the Gladstone Institute was able to identify hundreds of proteins in the mitochondria that undergo modification by lysine succinylation and its subsequent regulation by SIRT5. These findings have widespread implications for understanding metabolic function in both normal and disease states.

Slowdown of emotional recovery could be a warning sign for depression
(Medical Xpress)—Depression is a serious health problem that reduces the individual's quality life and creates a societal burden because of medical costs and decreased work productivity. Unfortunately, the transition from a normal to a severely depressed state can appear to occur suddenly, so observers cannot predict when someone is likely to become depressed. In a study published in the Proceedings of the National Academy of Sciences, Martin Scheffer of Wageningen University in the Netherlands and his colleagues have found that before people become severely depressed, they find it harder to bounce back from negative emotions. A reduction in resilience when encountering emotional setbacks can be a warning of a depressive episode.

Father's diet before conception plays crucial role in health of his offspring, study suggests
Mothers get all the attention. But a study led by McGill researcher Sarah Kimmins suggests that the father's diet before conception may play an equally important role in the health of their offspring. It also raises concerns about the long-term effects of current Western diets and of food insecurity.

Resistant flu virus keeps contagiousness
A mutant form of the H7N9 flu virus that is resistant to frontline drugs is just as contagious as its non-resistant counterpart, according to a lab test reported on Tuesday.

New findings reveal protein structure in rubella virus
(Medical Xpress)—Researchers have determined the structure of the rubella virus capsid protein, which is central to the virus's ability to assemble into an infectious particle and to infect humans.


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